I use iRule on Android and on iOS.
On my Nexus 7, sometimes on device wake the green connection symbol changes to a spinning icon for several seconds and then turns green. When this happens, the device buttons don't work.
I can get this to happen easily by toggling the Nexus 7's hardware suspend button, as seen in this video I took:
This happens even if I strip the number of panels, devices, and gateways down to a minimum.
This didn't happen for the first year or so I was using iRule on this device. Maybe a recent update to the app or the os has messed up the performance?